High-efficiency acylation catalyst and key pharmaceutical/agrochemical raw material
High-efficiency acylation catalyst and key pharmaceutical/agrochemical raw material
4-Dimethylaminopyridine (DMAP) is a highly active acylation, esterification, and transesterification catalyst, especially for sterically hindered alcohols and amines. Its catalytic activity can be 10,000–1,000,000 times that of pyridine, enabling mild conditions and high yields in pharmaceutical, agrochemical, dye, and flavor synthesis.
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It is used as a high-efficiency acylation catalyst in organic synthesis. Its catalytic activity is about 10,000 to 1 million times that of pyridine. It is especially suitable for the acylation reaction of alcohols and amines with large steric hindrance. Usually the catalyst dosage is only 0.01% to 5% of the moles of the reaction substrate. The reaction conditions are mild and the yield is high.
It is used in the production of statin lipid-lowering drugs, beta-(propyl)spiramycin and other raw materials. It is an important organic synthesis catalyst in the pharmaceutical industry.
In the fields of pesticides, dyes and spices, it is widely used in various types of acylation, esterification, transesterification and other reactions to improve reaction efficiency and product purity.
The reaction conditions are mild and the operation is simple. It is widely used in laboratory research and industrial production. It has the characteristics of low dosage and high catalytic efficiency.
Propionic Acid
Pyridine
Piperidine
2-Methylpyridine
3-Methylpyridine
4-Methylpyridine
2,2'-Bipyridine
2,3-Dimethylpyridine
3,5-Dimethylpyridine
2-Chloropyridine
2,3-Dichloropyridine
Tetrachloropyridine
Pentachloropyridine
2-Cyanopyridine
3-Cyanopyridine
4-Cyanopyridine
Dichloronicotinic Acid
2-Vinylpyridine
Ethylamine
Diethylamine
Triethylamine
Diketene
Methyl Acetoacetate
Formaldehyde
Acetaldehyde
Propanol
Propionaldehyde
Rifamycin S Sodium
Rifamycin S
Rifamycin O
Crotonaldehyde
Crotonic Acid
